Ancillary Ligand in Ternary CuII Complexes Guides Binding Selectivity toward Minor-Groove DNA
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چکیده
منابع مشابه
Hydrogen bond geometry in DNA-minor groove binding drug complexes.
The geometry of the hydrogen bonding interaction between DNA and minor-groove binding drugs has been analyzed from a sample of 22 crystal structures of DNA-drug complexes, retrieved from the Nucleic Acid Database. Seventy-seven interactions between the drugs and acceptor groups in the nucleotide bases can be classified as hydrogen bonds. Their geometry departs significantly from linearity since...
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DNA intercalating and minor groove binding compounds are new weapons in the battle against malignant diseases. These antineoplastic agents target the DNA molecule and interfere with the cell cycle leading to rapidly proliferating cell death. They are mainly derivates of a naturally occurring organic compound derived from a microorganism or plant. Intercalators usually act as topoisomerase I and...
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To date, high-resolution structures have been solved for five different architectural proteins complexed to their DNA target sites. These include TATA-box-binding protein, integration host factor (IHF), high mobility group I(Y)[HMG I(Y)], and the HMG-box-containing proteins SRY and LEF-1. Each of these proteins interacts with DNA exclusively through minor groove contacts and alters DNA conforma...
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ژورنال
عنوان ژورنال: The Journal of Physical Chemistry B
سال: 2020
ISSN: 1520-6106,1520-5207
DOI: 10.1021/acs.jpcb.0c09296